Models

 

Kformula Endocytosis


Uploader: Data From HepatoSys

Contributor: Andreas Deutsch, Data From HepatoSys, Lutz Brusch, Marino Zerial, Yannis Kalaidzidis

Other contributors: Perla Del Conte-Zerial, Jochen C Rink, Claudio Collinet

Model type: Not specified

Model format: SBML

Version: 1

Projects: HepatoSys

Organism: Not specified

Environment: Not specified

Scales: Cell

GTPases of the Rab family provide a molecular ID code to the generation, maintenance and transport of intracellular compartments. Here, we addressed the molecular design principles of endocytosis by focusing on the conversion of early endosomes into late endosomes, which entails replacement of Rab5 by Rab7. We demonstrate that intermodule interactions share similarities with the toggle switch described for the cell cycle. However, Rab5-to-Rab7 conversion is rather based on a newly characterized
...

Created: 29th Jul 2011 at 17:13   Last updated: 24th Feb 2012 at 14:08


 

Kformula Endocytosis: Rab5 domain formation on the early endosome (Rab5PDE)


Uploader: Data From HepatoSys

Contributor: Andreas Deutsch, Bianca Habermann, Data From HepatoSys, Lutz Brusch, Marino Zerial, Yannis Kalaidzidis

Other contributors: Perla Del Conte-Zerial, Jochen Rink

Model type: Partial differential equations (PDE)

Model format: SBML

Version: 1

Projects: HepatoSys

Organism: Not specified

Environment: Not specified

Scales: Cell

This model describes a core process during endocytosis. Intracellular vesicles called early endosomes contain the endocytosed cargo, e.g. signaling components like growth factors and RTKs, pathogens like viruses and nutrients like iron in transferrin. Early endosomes form an interacting pool of thousands of vesicles and jointly constitute the sorting and transport machinery in the endocytic pathway. Together with the cargo, membrane components travel to other compartments of the pathway which
...

Created: 1st Aug 2011 at 18:11   Last updated: 24th Feb 2012 at 16:55



Log in / Register

Need an account?
Sign up

Forgotten password?

Front Page

Virtual Liver Network

(v.0.22.0)

Related Projects and friends


Imprint Taverna workflow workbench myExperiment JWS Online ISATAB myGrid Sabio-RK BioPortal Semantic SBML

Powered by:

Ror-logo-32

Icons:
Silk icons 1.3
Crystal Clear icons