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Pdf Dynamic network reconstruction identified unexpected gene expression in primary hepatocytes after exchange of culture medium (FOSBE 2007 Contributed Paper)


Uploader: Data From HepatoSys

Contributor: Data From HepatoSys, Reinhard Guthke, Rolf Gebhardt, Sebastian Zellmer, Wolfgang Schmidt-Heck

Other contributors: Not specified

Version: 1

Projects: HepatoSys

Scales: Not specified

Primary hepatocytes were exposed to a stimulus by exchanging culture medium, thereby simulating changes in the blood composition. The expression of genes at different time points was recorded. Differentially expressed genes were clustered using fuzzy c-means algorithm into five groups. The arcs of the possible network were identified using the NetGenerator algorithm under the restriction of biological knowledge. The analysis was restricted to the main metabolic pathways of hepatocytes. The reverse
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Created: 1st Aug 2011 at 11:49   Last updated: 1st Aug 2011 at 13:43



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