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From Hepatocytes to Whole Liver Function: A Multi-Scale Model of Human Hepatic Galactose Metabolism

We present a multi-scale model of liver galactose metabolism bridging the scales from single-cell metabolism over the tissue level to the whole-organ. The model combines a detailed kinetic model of the cellular galactose metabolism with a tissue-scale perfusion model of the sinusoid. The metabolic capacity of the whole liver is modelled by integrating the heterogeneous contribution of sinusoids differing in blood-flow rates and tissue-architecture. The model was applied to the normal physiological state and to different variants of galactosemia caused by deficiency of the galactokinase (GALK), galactose-1-phosphate uridyl transferase (GALT), or UDP-galactose 4´-epimerase (GALE). The presented multi-scale model reproduces a wide range of experimental data ranging from multiple-indicator dilution and galactose elimination curves on organ and tissue scale, to alterations in key metabolites observed in galactosemia.

See also:
Model hepatocyte scale
http://seek.virtuelle-leber.de/models/138
Model sinusoidal unit scale
http://seek.virtuelle-leber.de/models/144
Presentation at VLN Retreat 2013
http://seek.virtuelle-leber.de/presentations/636

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Modelling Analysis

Projects: A1.1: Central liver metabolism and its regulation under nutritional chal..., C1: The role of blood flow in liver lobule function and morphology, C2: Organization of the sinusoidal system and the liver lobule - referen..., C3: Zonation of metabolism and its regulation

Investigation: Investigation: Multi-scale model galactose metabolism in the human liver

Study: Study : galactose metabolism in the liver

Biological problem addressed: Metabolic network

Organisms: Not Specified

help Contributors

[Matthias König]

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Cell, Liver lobule and Liver
Views: 1394
  • Created: 3rd Nov 2013 at 15:17
  • Last updated: 24th Jul 2015 at 13:30

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