Biological problem addressed 'Metabolic network'

Parents Modelling Analysis
Current Biological problem addressed Metabolic network
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Desktop From Hepatocytes to Whole Liver Function: A Multi-Scale Model of Human Hepatic Galactose Metabolism


ID: 71

Biological problem addressed: Metabolic network

Investigation: Investigation: Multi-scale model galactose meta...

Study: Study : Galactose metabolism in the liver

Models: 2 hidden items

Scales: Cell, Liver lobule and Liver

We present a multi-scale model of liver galactose metabolism bridging the scales from single-cell metabolism over the tissue level to the whole-organ. The model combines a detailed kinetic model of the cellular galactose metabolism with a tissue-scale perfusion model of the sinusoid. The metabolic capacity of the whole liver is modelled by integrating the heterogeneous contribution of sinusoids differing in blood-flow rates and tissue-architecture. The model was applied to the normal physiological
...

Created: 3rd Nov 2013 at 15:17   Last updated: 24th Jul 2015 at 13:30


 

Desktop Kinetic modelling of hepatic glucose metabolism


Contributor: Matthias König

Projects: A1.1: Central liver metabolism and its regulation under nutritional chal..., A3.4: Linking signalling to metabolic functions

Organisms: Not Specified

SOPs: No SOPs

Data files: No Data files

Scales: Cell and Liver

No description specified

Created: 3rd Nov 2013 at 16:43   Last updated: 24th Jul 2015 at 13:31



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